Gualtiero Alvisi's profile

I'm male and 32

What I do

I am using live cell imaging based approaches to study viral DNA polymerases nuclear transport regulation and protein-protein interactions. I am also investigating the effect of post-translational modifications in regulating the activity of the aforementioned proteins. The long term goal is to develop novel anti viral drugs

Affiliations

Current

Location

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Interests

Herpesviral DNA polymerases
Nuclear transport regulation
Nuclear architecture

Projects

Gualtiero Alvisi has not yet listed any projects.

Publications

  • Alvisi G, Rawlinson S, Ghildyal R, Ripalti A, Jans D. Regulated nucleocytoplasmic trafficking of viral gene products: a therapeutic target? Biochimica et biophysica acta 1784 (1) , 213-27 (2008) (Epub 31 Aug 2007) PubMed ID:(17933596)

  • Alvisi G, Musiani D, Jans D, Ripalti A. An importin alpha/beta-recognized bipartite nuclear localization signal mediates targeting of the human herpes simplex virus type 1 DNA polymerase catalytic subunit pUL30 to the nucleus. Biochemistry 46 (32) , 9155-63 (2007) (Epub 20 Jul 2007) PubMed ID:(17640102)

  • Alvisi G, Jans D, Ripalti A. Human cytomegalovirus (HCMV) DNA polymerase processivity factor ppUL44 dimerizes in the cytosol before translocation to the nucleus. Biochemistry 45 (22) , 6866-72 (2006) PubMed ID:(16734423)

  • Alvisi G, Ripalti A, Ngankeu A, Giannandrea M, Caraffi S, Dias M, Jans D. Human cytomegalovirus DNA polymerase catalytic subunit pUL54 possesses independently acting nuclear localization and ppUL44 binding motifs. Traffic (Copenhagen, Denmark) 7 (10) , 1322-32 (2006) (Epub 15 Aug 2006) PubMed ID:(16911590)

  • Alvisi G, Jans D, Guo J, Pinna L, Ripalti A. A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44. Traffic (Copenhagen, Denmark) 6 (11) , 1002-13 (2005) PubMed ID:(16190981)

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