• William Gunn's profile

    • What I do

      I am a senior graduate student at the Tulane Center for Gene Therapy.

      My dissertation is entitled “Investigating the Role of Human Multipotent Mesenchymal Stromal Cells in the Repair of Bone.”

      An updated list of my publications can be found here.

      My reading list at Connotea is here.

      I keep an open science journal and weblog at Synthesis.

      My Hirsch Index is 5.
      My Age Weighted Citation Rate is: 22.08

    • Affiliations

      Current

    • Interests

      Adult Stem Cell Research, Bone Biology, Statistical Analysis, Expert Systems, and Data Mining.

    • Projects

      Completed Work:

      As part of my graduate research, I have participated in research showing:

      • That MSCs contribute to bone repair by proliferating under the influence of Dkk1 and then undergoing osteogenesis to effect remodeling at the site of injury.
      • That Dkk1 is secreted by myeloma cells and acts upon MSCs to result in osteolytic lesions in bone that are resistant to remodeling.
      • That remodeling can occur if the effect of Dkk1 on MSCs is blocked using small molecule activators of Wnt signaling.

      Experiments in Progress:

      • Show that osteoclasts are upregulated while osteoblasts are deficient in an animal model of multiple myeloma.
      • Show that Dkk1 is produced by the tumors in vivo, and Dkk1 levels are correlated with the magnitude of the defect.
      • Show that MSCs derived from these animals are different in a similar fashion to the MSCs derived from myeloma patients.
      • Show that I can treat the animals in this model with the small molecule Wnt activators and reduce the size of tumors and incidence of osteolytic lesions.

    • Publications

      • Gregory C. Dkk-1-derived Synthetic Peptides and Lithium Chloride for the Control and Recovery of Adult Stem Cells from Bone Marrow Journal of Biological Chemistry 280 (3) , 2309 - 232 (Epub 20 Nov 2004) doi: 10.1074/jbc.M406275200

      • Gregory C, Green A, Lee N, Rao A, Gunn W. The promise of canonical Wnt signaling modulators in enhancing bone repair. Drug news & perspectives 19 (8) , 445-52 PubMed ID:(17160144)

      • Gregory C, Gunn W, Peister A, Prockop D. An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Analytical biochemistry 329 (1) , 77-84 PubMed ID:(15136169)

      • Gregory C, Gunn W, Reyes E, Smolarz A, Munoz J, Spees J, Prockop D. How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow. Annals of the New York Academy of Sciences 1049 , 97-106 PubMed ID:(15965110 )

      • Gunn W, Conley A, Deininger L, Olson S, Prockop D, Gregory C. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem cells (Dayton, Ohio) 24 (4) , 986-91 (Epub 17 Nov 2005) PubMed ID:(16293576)

      view all
Sign in

New to Nature Network?
Sign up today!

Search people
Send an invite

Advertisement