Alex Hansen's profile
I'm 27
What I do
5th year Graduate Student at the University of Michigan, soon to be moving on to a postdoc at the University of Toronto. I’m a biomolecular NMR spectroscopist.
Affiliations
Current affiliations
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- Position
- Graduate Student
- Company
- Department of Chemistry, University of Michigan
- Duration
- 2003 - Present
Location
- City:
- None chosen
- Hub:
- None chosen
Interests
I’m interested in using NMR spectroscopy to understand the dynamics of large biomolecular systems in a way that no other technique can. NMR provides atomic level resolution of the ongoings of these systems and can even tackle complexes up to 1.1 MDa and beyond. I would like to push the current limitations and develop techniques for studying nucleic acids of similar complexity as the MDa protein complexes.
Projects
Currently developing 13C Relaxation Dispersion experiments for large, uniformly 13C/15N-labeled nucleic acids.
Publications
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Bailor M, Musselman C, Hansen A, Gulati K, Patel D, Al-Hashimi H. Characterizing the relative orientation and dynamics of RNA A-form helices using NMR residual dipolar couplings. Nature protocols (6) , 1536-46 (2007) PubMed ID:(17571061 )
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Hansen A, Al-Hashimi H. Dynamics of large elongated RNA by NMR carbon relaxation. Journal of the American Chemical Society (51) , 16072-82 (2007) (Epub 30 Nov 2007) PubMed ID:(18047338 )
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Hansen A, Al-Hashimi H. Insight into the CSA tensors of nucleobase carbons in RNA polynucleotides from solution measurements of residual CSA: towards new long-range orientational constraints. Journal of magnetic resonance (San Diego, Calif. : 1997) (2) , 299-307 (2006) (Epub 23 Jan 2006) PubMed ID:(16431143 )
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Hickok R, Wedge S, Hansen A, Morris K, Billiot F, Warner I. Pulsed field gradient NMR investigation of solubilization equilibria in amino acid and dipeptide terminated micellar and polymeric surfactant solutions Magn. Reson. Chem. (12) , 755 - 761 (2002) doi: 10.1002/mrc.1099
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