Sudhir Sahasrabudhe's profile
What I do
I am the scientific founder and CSO of Prolexys Pharmaceuticals, Inc., a biopharmaceutical company focused on discovering small molecule drugs that act at novel therapeutic targets. The Company’s therapeutic focus is on cancer and cardiovascular indications. We have utilized proteomics-related techniques to identify drug candidates that interact with targets of interest. The result of targeted drug discovery work at Prolexys is a pipeline of product candidates. Lead programs include:
a) PRLX 93936 small molecule clinical candidate that shows selective lethality towards tumor cells, including those with activated RAS pathway. This compound is currently in Phase I clinical trial.
b) the colon cancer program with novel small molecule compounds targeting the beta-catenin signaling cascade and
c) HSP20 antagonists, identified as protein interaction inhibitors from targets validated in asthma and vasorelaxation.
Affiliations
Current affiliations
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- Position
- Chief Scientific Officer
- Company
- Prolexys Pharmaceuticals, Inc.
- Further information
Location
- City:
- None chosen
- Hub:
- None chosen
Interests
molecular pharmacology, clinical trial design, drug development, parkinson’s disease, neurodegeneration, oncology
Projects
1. Identification of genotype-selective small molecules with selective anti-tumor activity
2. Beta-catenin pathway
Publications
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Kaltenbach L, Romero E, Becklin R, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha G, Ukani L, Chepanoske C, Zhen Y, Sahasrabudhe S, Olson J, Kurschner C, Ellerby L, Peltier J, Botas J, Hughes R. Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration PLoS Genet (5) (2007) doi: 10.1371/journal.pgen.0030082
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Yagoda N, von Rechenberg M, Zaganjor E, Bauer A, Yang W, Fridman D, Wolpaw A, Smukste I, Peltier J, Boniface J, Smith R, Lessnick S, Sahasrabudhe S, Stockwell B. RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels Nature (7146) , 865 - 869 (2007) doi: 10.1038/nature05859
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Mukherji M, Bell R, Supekova L, Wang Y, Orth A, Batalov S, Miraglia L, Huesken D, Lange J, Martin C, Sahasrabudhe S, Reinhardt M, Natt F, Hall J, Mickanin C, Labow M, Chanda S, Cho C, Schultz P. Genome-wide functional analysis of human cell-cycle regulators. Proceedings of the National Academy of Sciences of the United States of America (40) , 14819-24 (2006) (Epub 25 Sep 2006) PubMed ID:(17001007)
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LaCount D, Vignali M, Chettier R, Phansalkar A, Bell R, Hesselberth J, Schoenfeld L, Ota I, Sahasrabudhe S, Kurschner C, Fields S, Hughes R. A protein interaction network of the malaria parasite Plasmodium falciparum Nature (7064) , 103 - 107 (2005) doi: 10.1038/nature04104
Sudhir Sahasrabudhe's activity on Nature Network
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