Silvia Paracchini's profile
What I do
I am working on the genetic basis of dyslexia. In particular I am working on the KIAA0319 candidate gene.
Affiliations
Current affiliations
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- Position
- Postdoctoral research scientist
- Company
- Wellcome Trust Centre for Human Genetics
- Further information
Location
- City:
- None chosen
- Hub:
- None chosen
Interests
I am interested in dissecting the genetic component contributing to the development of dyslexia and to understand which biological machanisms are at the basis of cognitive functions.
Projects
My main interest is the functional characterisation of the dyslexia candidate KIAA0319, in particular exploring the role of this protein in neuronal migration. I am also interested to test whether the KIAA0319 might have a role in controlling other cognitive function and whether it has an effected on reading abilities in general, rather than contributing specifically to the development of dyslexia.
I am involved in collaborative studies aiming to identify other genetic components at the basis of dyslexia.
Publications
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The Genetic Lexicon of Dyslexia. PubMed ID:(17444811)
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Francks C, Paracchini S, Smith S, Richardson A, Scerri T, Cardon L, Marlow A, MacPhie I, Walter J, Pennington B, Fisher S, Olson R, DeFries J, Stein J, Monaco A. A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. American journal of human genetics (6) , 1046-58 (Epub 22 Oct 2004) PubMed ID:(15514892)
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Paracchini S, Thomas A, Castro S, Lai C, Paramasivam M, Wang Y, Keating B, Taylor J, Hacking D, Scerri T, Francks C, Richardson A, Wade-Martins R, Stein J, Knight J, Copp A, Loturco J, Monaco A. The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Human molecular genetics (10) , 1659-66 (Epub 06 Apr 2006) PubMed ID:(16600991)
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