• Sayandip Mukherjee's profile

    I'm male London

    • What I do

      I am a postdoctoral research fellow working with Dr. Adrian Thrasher and Dr. Nicola Philpott at the Wolfson Centre for Gene Therapy of Childhood Diseases,Institute of Child Health, University College London, London, UK.

    • Affiliations

      Current

    • Interests

      I am working on several projects related to development of novel lentiviral vectors for the purpose of gene therapy. Briefly, I am working on the adoption of non-integrating lentiviral vectors for delivery into human skin using microneedles. This will be for the purpose of vaccination. My other objective is to develop a vector system for targeting the provirus carrying the transgene of interest into a specified region of the genome, something which has not been achieved so far. This, if accomplished, will be immensely useful to allay fears of random integration of lentivectors leading to undesired effects.

    • Projects

      1. Development of lentivectors for microneedle delivery to human skin.
      2. Development of a lentivector system for targeted delivery of transgene to a particular genetic locus in the human genome.

    • Publications

      • Mukherjee S, Lee H, Pacchia A, Ron Y, Dougherty J. A HIV-2-based self-inactivating vector for enhanced gene transduction. Journal of biotechnology 127 (4) , 745-57 (Epub 18 Sep 2006) PubMed ID:(16979253)

      • Mukherjee S, Lee H, Ron Y, Dougherty J. Proviral progeny of heterodimeric virions reveal a high crossover rate for human immunodeficiency virus type 2. Journal of virology 80 (24) , 12402-7 (Epub 04 Oct 2006) PubMed ID:(17020945 )

      • Pacchia A, Mukherjee S, Dougherty J. Choice and use of appropriate packaging cell types. Methods in molecular biology (Clifton, N.J.) 229 , 29-42 PubMed ID:(12824619)

      • Zhuang J, Mukherjee S, Ron Y, Dougherty J. High rate of genetic recombination in murine leukemia virus: implications for influencing proviral ploidy. Journal of virology 80 (13) , 6706-11 PubMed ID:(16775360)

      view all

    • Contact

      email:
      MSN:
      sayandip_m@hotmail.com
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