Ray Chan's profile
What I do
I’m a 3rd year grad student in the Neuro-Oncology group led by Prof Peter Collins and Dr Koichi Ichimura. We are part of the Pathology Department in Tennis Court Road, but our lab is on the Addenbrooke’s campus.
Our main interests lie in understanding genetic alterations of human central nervous system tumours using standard molecular genetic techniques and microarrays.
Our main expertise is in the use of array-CGH, for which we have generated a whole genome 1Mb array, and chromosomal specific tiling arrays (1,6,9,10,17,22). We also make use of commercial oligonucleotide arrays by OGT and Agilent, and expression arrrays by Affymetrix.
I have constructed a tiling array-CGH covering interesting regions of chromosome 9, 10, 12, 19, 21 pinpointing novel microdeletions and amplifications.
Affiliations
Current affiliations
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- Position
- PhD Student
- Company
- University of Cambridge, Department of Pathology
- Further information
Location
- City:
- None chosen
- Hub:
- None chosen
Interests
My particular interests are in oligodendrogliomas, a particularly chemosensitive glial tumour, with characteristic deletions in chromosomal arms 1p and 19q, caused by a translocation and deletion event.
I’m interested in DNA sequence, copy number, epigenetic, and expression changes that may pinpoint the identity of novel tumour suppressor genes and oncogenes in this tumour type.
Most recently, I’m working on identifying a putative fusion gene caused by the chromosome 1 and 19 translocation event.
Projects
Genome-Wide Array-CGH of Oligodendroglial Tumours.
Chromosome 19 Array-CGH screening of Oligodendroglial and Astrocytic Tumors
Publications
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Maudsley S, Davidson L, Pawson A, Chan R, López de Maturana R, Millar RP. Gonadotropin-Releasing Hormone (GnRH) Antagonists Promote Proapoptotic Signaling in Peripheral Reproductive Tumor Cells by Activating a G{alpha}i-Coupling State of the Type I GnRH Receptor Cancer Research , 7533-7544 (2004)