• Philipp Selenko's profile

    I'm male and 35 Boston

    • What I do

      I employ high-resolution NMR spectroscopy to study proteins inside live cells. The overall aim is to develop tools for observing biomolecules in their native cellular environments and at atomic resolution. In particular, we analyze the structural and functional in vivo properties of proteins that do not display ordered three-dimensional conformations in vitro. Since many of these ‘intrinsically disordered proteins (IDPs)’ participate in human neurodegenerative disorders (amyloid diseases), we focus on elucidating their native in vivo characteristics inside live cells.

    • Affiliations

      Current

    • Interests

      Conformational and functional properties of biomolecules inside live cells.

    • Projects

      Develop and apply atomic resolution methods to visualize biological processes in vivo, with particular emphasis on Intrinsically Disordered Proteins (IDPs).

    • Publications

      • In situ observation of protein phosphorylation by high-resolution NMR spectroscopy. Nature structural & molecular biology (2008) (Epub 24 Feb 2008) PubMed ID:(18297086)

      • Selenko P, Serber Z, Gadea B, Ruderman J, Wagner G. Quantitative NMR analysis of the protein G B1 domain in Xenopus laevis egg extracts and intact oocytes. Proceedings of the National Academy of Sciences of the United States of America 103 (32) , 11904-9 (Epub 27 Jul 2006) PubMed ID:(16873549)

      • Selenko P, Wagner G. Looking into live cells with in-cell NMR spectroscopy. Journal of structural biology 158 (2) , 244-53 (Epub 10 Apr 2007) PubMed ID:(17502240)

      • Selenko P, Wagner G. NMR mapping of protein interactions in living cells. Nature methods 3 (2) , 80-1 PubMed ID:(16432515)

      • Serber Z, Selenko P, Hänsel R, Reckel S, Löhr F, Ferrell J, Wagner G, Dötsch V. Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy. Nature protocols 1 (6) , 2701-9 PubMed ID:(17406526)

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