We have recently developed a data integration platform to facilitate mapping and analysis of networks from RNAi and gene expression data. This platform will now be extended to cross-correlate diverse biological datasets to facilitate the detailed mapping of key pathways involved in breast cancer tumourigenesis and metastasis development, creating a dynamic normal breast and breast cancer ‘interactome’. We will project information onto this network, including kinetic data that will allow mathematical modelling of dynamic system behaviour. We will also model docking of ligands to protein structures of key network components to understand the specificity of drug binding and to guide development of new and better lead compounds.