• Miguel Allende's profile

    • What I do

      I am a biologist with a position as an Associate Professor at the University of Chile in Santiago. I have been working for ten years on zebrafish developmental biology and molecular genetics. I am also part of a wider group of scientists funded by the Millennium Science Initiative, the Center for Genomics of the Cell, CGC of which I am Scientific Director. I am also President of the Chilean Society for Cell Biology (term 2007-2008).

      Blog:
      Miguel Allende's blog

    • Affiliations

      Current

      Past

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    • Interests

      In my lab, we are interested in development of neural cells during embryogenesis. In recent years, we have focused on mechanosensory cells in the zebrafish as a model to understand the genetic basis of their development. We are working at present towards dissecting the molecular mechanisms involved in hair cell regeneration. Other projects include immune system development in fish, cell migration, effect of environmental contaminants on fish, biomedical applications of zebrafish and genomic analysis of salmonids.

    • Projects

      • Development and regeneration of hair cells in the zebrafish lateral line
      • Effects of copper on fish development
      • Assays for detecting environmental effects of contaminants
      • Migration of immune cells
      • Fish as biomedical models

    • Publications

      • Bergeron S, Milla L, Villegas R, Shen M, Burgess S, Allende M, Karlstrom R, Palma V. Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos. Genomics 91 (2) , 165-77 (2008) (Epub 11 Dec 2007) PubMed ID:(18055165)

      • Blanco M, Barrallo-Gimeno A, Acloque H, Reyes A, Tada M, Allende M, Mayor R, Nieto M. Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (Cambridge, England) 134 (22) , 4073-81 (2007) PubMed ID:(17965052 )

      • Hernández P, Olivari F, Sarrazin A, Sandoval P, Allende M. Regeneration in zebrafish lateral line neuromasts: expression of the neural progenitor cell marker sox2 and proliferation-dependent and-independent mechanisms of hair cell renewal. Developmental neurobiology 67 (5) , 637-54 (2007) PubMed ID:(17443814)

      • Rojas D, Perez-Munizaga D, Centanin L, Antonelli M, Wappner P, Allende M, Reyes A. Cloning of hif-1alpha and hif-2alpha and mRNA expression pattern during development in zebrafish. Gene expression patterns : GEP 7 (3) , 339-45 (2007) (Epub 15 Aug 2006) PubMed ID:(16997637)

      • Villablanca E, Pistocchi A, Court F, Cotelli F, Bordignon C, Allende M, Traversari C, Russo V. Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the thymus of zebrafish embryos. Journal of immunology (Baltimore, Md. : 1950) 179 (1) , 357-64 (2007) PubMed ID:(17579056)

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