Linda Nevin's profile
What I do
I am a post-doctoral fellow in Herwig Baier’s laboratory at UCSF, studying the development of synaptic layers in the zebrafish visual system. The study of synaptic specificity is quite tractable in the inner plexiform layer of the retina, where bipolar cells, amacrine cells, and ganglion cells project neurites and form synapses. The correct targeting of these neurites is believe to be important for visual function—the synapses in the IPL mediate direction selectively and color opponency, for examples. I am studying the role of neuronal activity in ordering these layers, and have completed a forward genetic screen to find genes involved in their development. At present I am working on the gene identification for an interesting mutant with aberrantly targeted IPL neurites, among other projects.
Affiliations
Current affiliations
-
- Position
- PhD Student, Post-doctoral fellow
- Company
- Baier Laboratory, University of California, San Francisco
- Duration
- 2002 - 2007
- Further information
Past affiliations
-
- Position
- Undergraduate
- Company
- Stanford University
- Duration
- 1995 - 1999
- Further information
-
- Position
- Student
- Company
- La Reina High School
- Duration
- 1991 - 1995
- Further information
Location
- City:
- San Francisco, California, United States
- Hub:
- San Francisco Bay Area
Interests
Topics:
Visual system development and function
Evolutionary biology
Molecular psychiatry
Music and the brain
Career:
In the longer term, I am interested in scientific editing, scientific writing, and intellectual property law.
Projects
- Characterization of the synaptic layers of the zebrafish inner plexiform layer—shown here is a composite I made of four labeled retinal cell types and the IPL sublaminae they innervate
- Assessing the role of neuronal activity in the development of synaptic layers in the zebrafish visual system
- Identification of genes responsible for synaptic targeting in the visual system
- Study of the role of synaptic vesicle cycling in neuromodulator expression in the hypothalamus, in collaboration with Holly Ingraham’s group
- Study of the genetic basis for unilateral anophthalmia and coloboma in human mutants, in collaboration with Anne Slavotinek’s group
- Characterization of neurons of the optic tectum, the major retinorecipient structure in the zebrafish brain (Gosse et al, 2008)
Publications
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Your Brain on Music UCSF Synapse (2008)
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Gosse N, Nevin L, Baier H. Retinotopic order in the absence of axon competition. Nature (7189) , 892-5 (2008) (Epub 26 Mar 2008) PubMed ID:(18368050)
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Muto A, Orger M, Wehman A, Smear M, Kay J, Page-McCaw P, Gahtan E, Xiao T, Nevin L, Gosse N, Staub W, Finger-Baier K, Baier H. Forward genetic analysis of visual behavior in zebrafish. PLoS genetics (5) , e66 (2005) (Epub 25 Nov 2005) PubMed ID:(16311625)
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Sipkins D, Cheresh D, Kazemi M, Nevin L, Bednarski M, Li K. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nature medicine (5) , 623-6 (1998) PubMed ID:(9585240)
Linda Nevin's activity on Nature Network
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