Jan Bieschke's profile
What I do
Looking at protein misfolding processes and the relationship between misfolded protein structures and toxicity.
Affiliations
Current affiliations
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- Position
- Helmholtz Group Leader
- Company
- Max Delbrück Center for Molecular Medicine
- Further information
Location
- City:
- None chosen
- Hub:
- None chosen
Interests
Protein biochemistry and biophysics, atomic force microscopy, single molecule fluorescence
Projects
Jan Bieschke has not yet listed any projects.
Publications
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Bieschke J, Siegel S, Fu Y, Kelly J. Alzheimer's Abeta Peptides Containing an Isostructural Backbone Mutation Afford Distinct Aggregate Morphologies but Analogous Cytotoxicity. Evidence for a Common Low-Abundance Toxic Structure(s)? Biochemistry (1) , 50-9 (2008) (Epub 14 Dec 2007) PubMed ID:(18078350)
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Cohen E, Bieschke J, Perciavalle R, Kelly J, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science (New York, N.Y.) (5793) , 1604-10 (2006) (Epub 10 Aug 2006) PubMed ID:(16902091)
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Bieschke J, Zhang Q, Powers E, Lerner R, Kelly J. Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation. Biochemistry (13) , 4977-83 (2005) PubMed ID:(15794636)
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Bieschke J, Weber P, Sarafoff N, Beekes M, Giese A, Kretzschmar H. Autocatalytic self-propagation of misfolded prion protein. Proceedings of the National Academy of Sciences of the United States of America (33) , 12207-11 (2004) (Epub 05 Aug 2004) PubMed ID:(15297610)
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Bieschke J, Giese A, Schulz-Schaeffer W, Zerr I, Poser S, Eigen M, Kretzschmar H. Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets. Proceedings of the National Academy of Sciences of the United States of America (10) , 5468-73 (2000) PubMed ID:(10805803)