John Hanover's profile
What I do
Glycobiology, Signaling, Cell Biology, Organelle Biogenesis, Human Disease
Affiliations
Current affiliations
-
- Position
- Chief, LABORATORY OF CELL BIOCHEMISTRY AND BIOLOGY, NIDDK, NIH
- Company
- NIDDK, NIH
- Duration
- 1985 - Present
- Further information
Location
- City:
- Bethesda, Maryland, United States
- Hub:
- None chosen
Interests
Our laboratory focuses on (1) the mechanism of nuclear transport and (2) the molecular features of a novel, glycan-dependent, signal transduction cascade. Using reverse genetics, knockout, and other transgenic models we are currently exploring the role of these essential pathways in signal transduction and pathogenesis of diabetes mellitus.
Projects
Research Focus I: The Hexosamine Signaling Pathway: Key Cellular Sensor of Nutrient Excess deregulated in Diabetes
Research Focus II: A Role of the Hexosamine Signaling Pathway in Tauopathy: A C. elegans model
Research Focus III: Calmodulin-Dependent Nuclear Import
Publications
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Love D. The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code" Science's STKE (312) , re13 - re13 (2005) (Epub 22 Nov 2005) doi: 10.1126/stke.3122005re13
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