Klaus Podar's profile
What I do
My research interests focus on the elucidation of signaling pathways leading to Multiple Myeloma cell growth, proliferation and migration thereby aiming to identify potential new therapeutic targets. Specifically I defined the pathophysiologic role of VEGF, PKCs, Src/ Hck, lipid rafts/ caveolin, and c-Abl/ c-Jun in Multiple Myeloma. Derived clinical trials are now already evaluating the therapeutic role of anti- angiogenic compounds alone or in combination with other novel and conventional therapies to improve patient outcome.
Affiliations
Current affiliations
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- Position
- Instructor in Medicine
- Company
- Dana-Farber Cancer Institute/ Harvard Medical School
- Further information
Location
- City:
- None chosen
- Hub:
- Boston
Interests
No interests have been listed by Klaus Podar.
Projects
Klaus Podar has not yet listed any projects.
Publications
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Podar K, Anderson K. Caveolin-1 as a potential new therapeutic target in multiple myeloma. Cancer letters (1) , 10-5 PubMed ID:(16473666 )
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Podar K, Anderson K. Inhibition of VEGF signaling pathways in multiple myeloma and other malignancies. Cell cycle (Georgetown, Tex.) (5) , 538-42 (Epub 31 Mar 2007) PubMed ID:(17351339)
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Podar K, Anderson K. The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications. Blood (4) , 1383-95 (Epub 07 Oct 2004) PubMed ID:(15471951)
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Podar K, Catley L, Tai Y, Shringarpure R, Carvalho P, Hayashi T, Burger R, Schlossman R, Richardson P, Pandite L, Kumar R, Hideshima T, Chauhan D, Anderson K. GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment. Blood (9) , 3474-9 (Epub 26 Nov 2003) PubMed ID:(14644994)
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Podar K, Hideshima T, Chauhan D, Anderson K. Targeting signalling pathways for the treatment of multiple myeloma. Expert opinion on therapeutic targets (2) , 359-81 PubMed ID:(15934921)
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