Francois-Pierre Martin's profile

I'm male and 28

What I do

Metab/lonomics, Nutrimetabonomics, Systems Biology

Affiliations

Current

Past

Location

City:
Lausanne, Canton de Vaud, Switzerland
Hub:
Geneva

Interests

I have joined the team of nutritional metabonomics at Nestle Research Center, Switzerland in November 2006 as a research scientist.

I used to be a PhD student based in London, at the Department of Biomolecular Medicine, Imperial College London, UK.

I have investigated the effects of the gut microflora on the systemic and tissue-specific metabolic profiles of mammalian organism. The study was aimed at investigating the effects of live bacterial (probiotics) and oligosaccharides (prebiotics) supplementations on the gut microflora and metabolism, health and nutritional status of mice.

Through this experience, I acquired robust skills using NMR-based metabonomic techniques on biofluids (static and flow modes) and intact tissues (magic-angle-spinning NMR spectroscopy). I also applied UPLC-MS techniques to characterise the metabolic profile of intestinal fluids and tissue extracts.

I am also familiar with multivariate data analysis techniques such as principal components analysis and partial least squares analysis that I used for the comprehensive analysis of this complex set of data (NMR spectroscopic and LC-MS data) and integration with conventional microbiological data.

Projects

More info soon

English:
http://www.nature.com/nrmicro/journal/v6/n3/full/nrmicro1864.html

http://sciencenow.sciencemag.org/cgi/content/full/2008/115/2

http://sciencenow.sciencemag.org/cgi/content/full/2007/523/2

http://www.sciencemag.org/cgi/content/full/318/5853/1045b

http://news.bbc.co.uk/1/hi/health/7184011.stm

http://www.telegraph.co.uk/earth/main.jhtml?xml=/earth/2008/01/15/scibiotic115.xml

http://www.nhs.uk/News/2007/January08/Pages/Probioticsandmice.aspx

Chinese: http://www.sciencetimes.com.cn/htmlpaper/2008117103152858861.html

Publications

  • Metabonomic and Microbiological Analysis of the Dynamic Effect of Vancomycin-Induced Gut Microbiota Modification in the Mouse. Journal of proteome research (2008) (Epub 13 Aug 2008) PubMed ID:(18698804 )

  • Martin F, Wang Y, Sprenger N, Yap I, Lundstedt T, Lek P, Rezzi S, Ramadan Z, van Bladeren P, Fay L, Kochhar S, Lindon J, Holmes E, Nicholson J. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Molecular systems biology 4 , 157 (2008) (Epub 15 Jan 2008) PubMed ID:(18197175)

  • Martin F, Wang Y, Sprenger N, Yap I, Rezzi S, Ramadan Z, PerĂ©-Trepat E, Rochat F, Cherbut C, van Bladeren P, Fay L, Kochhar S, Lindon J, Holmes E, Nicholson J. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. Molecular systems biology 4 , 205 (2008) (Epub 15 Jul 2008) PubMed ID:(18628745)

  • PERS T, MARTIN F, VERDICH C, HOLST C, JOHANSEN J, ASTRUP A, POLAK J, MARTINEZ J, REZZI S, BLAAK E. Prediction of fat oxidation capacity using 1H-NMR and LC-MS lipid metabolomic data combined with phenotypic data Chemometrics and Intelligent Laboratory Systems (2008) doi: 10.1016/j.chemolab.2008.03.008

  • REZZI S, VERA F, MARTIN F, WANG S, LAWLER D, KOCHHAR S. Automated SPE-RP-HPLC fractionation of biofluids combined to off-line NMR spectroscopy for biomarker identification in metabonomics☆ Journal of Chromatography B (2008) doi: 10.1016/j.jchromb.2008.04.001

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