Francesco Lotti's profile

What I do

Interested to the characterization of the molecular functions of the SMN (Survival of motor neurons) protein complex and to define its role in the motor neuron degenerative disease Spinal Muscular Atrophy (SMA).
PrometeoNetwork co-founder (www.prometeonetwork.com)

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Publications

  • Battle D, Kasim M, Yong J, Lotti F, Lau C, Mouaikel J, Zhang Z, Han K, Wan L, Dreyfuss G. The SMN complex: an assembly machine for RNPs. Cold Spring Harbor symposia on quantitative biology 71 , 313-20 (2006) PubMed ID:(17381311 )

  • Battle D, Lau C, Wan L, Deng H, Lotti F, Dreyfuss G. The Gemin5 protein of the SMN complex identifies snRNAs. Molecular cell 23 (2) , 273-9 (2006) PubMed ID:(16857593)

  • Menegon A, Bonanomi D, Albertinazzi C, Lotti F, Ferrari G, Kao H, Benfenati F, Baldelli P, Valtorta F. Protein kinase A-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience 26 (45) , 11670-81 (2006) PubMed ID:(17093089)

  • Urbinati F, Lotti F, Facchini G, Montanari M, Ferrari G, Mavilio F, Grande A. Competitive engraftment of hematopoietic stem cells genetically modified with a truncated erythropoietin receptor. Human gene therapy 16 (5) , 594-608 (2005) PubMed ID:(15916484)

  • Testa A, Lotti F, Cairns L, Grande A, Ottolenghi S, Ferrari G, Ronchi A. Deletion of a negatively acting sequence in a chimeric GATA-1 enhancer-long terminal repeat greatly increases retrovirally mediated erythroid expression. The Journal of biological chemistry 279 (11) , 10523-31 (2004) (Epub 29 Dec 2003) PubMed ID:(14701820 )

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