Antony Oliver's profile
What I do
I work in the Section of Structural Biology, at the Institute of Cancer Research, in the laboratory of Laurence Pearl. Our group is principally interested in proteins that facilitate the repair of damaged DNA, with a particular emphasis on determining their structures by X-ray crystallography.
Affiliations
Current affiliations
-
- Position
- Senior Scientist
- Company
- The Institute of Cancer Research
- Duration
- 2000 - Present
- Further information
Past affiliations
-
- Position
- Post-Doctoral Researcher
- Company
- Biophysics Laboratories, University of Portsmouth
- Duration
- 1997 - 2000
- Further information
Location
- City:
- London, England, United Kingdom
- Hub:
- London
Interests
Cancer Therapeutics, Rational Drug Design, X-ray Crystallography, Biophysics, DNA Repair, Recombinant Protein Expression and Purification
Projects
Proteins involved in DNA Repair
Publications
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Pike A, Rellos P, Niesen F, Turnbull A, Oliver A, Parker S, Turk B, Pearl L, Knapp S. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites EMBO J (4) , 704 - 714 (2008) (Epub 31 Jan 2008) doi: 10.1038/emboj.2008.8
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OLIVER A, KNAPP S, PEARL L. Activation segment exchange: a common mechanism of kinase autophosphorylation? Trends in Biochemical Sciences (8) , 351 - 356 (2007) doi: 10.1016/j.tibs.2007.06.004
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Dore A, Kilkenny M, Jones S, Oliver A, Roe S, Bell S, Pearl L. Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity Nucleic Acids Research (16) , 4515 - 4526 (2006) (Epub 26 Aug 2006) doi: 10.1093/nar/gkl623
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Oliver A, Paul A, Boxall K, Barrie S, Aherne G, Garrett M, Mittnacht S, Pearl L. Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange EMBO J (13) , 3179 - 3190 (2006) (Epub 22 Jun 2006) doi: 10.1038/sj.emboj.7601209
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Oliver A, Amé J, Roe S, Good V, de Murcia G, Pearl L. Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic acids research (2) , 456-64 (2004) (Epub 22 Jan 2004) PubMed ID:(14739238)
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