Current affiliations

• Position

  Company

  Nitroceutic LLC

  Further information

City:

None chosen

Hub:

Boston

NO physiology: In particular how NO is used as a regulatory molecule, and how because each NO sensor only senses the sum of NO from all NO sources, a change in the basal level of NO affects the operating point of all NO regulated pathways with no threshold (that is, any change in the basal NO level affects the output).

Important NO mediated pathways: include mitochondria biogenesis, the ATP setpoint, steroid synthesis, bone density, vascular tone, O2 consumption by cytochrome c oxidase, metallization of Zn finger proteins, to name a few. All these pathways are characteristically affected with no threshold by changes in basal NO. It is a shift in setpoint and not dysregulation.

All NO pathways are coupled, because NO from all sources is summed to produce an effect. There is cross-talk between all NO pathways. This is why NO therapies are so difficult (due to side effects) and why (I think) many seemingly disparate disorders have symptoms that are so similar.

Long term regulation (years) mitochondria number in neurons.

Effect of low basal NO in exacerbating degenerative disorders via effects on ATP regulation, oxidative stress and cellular repair.

Commercialization topical ammonia oxidizing bacteria therapies to restore normal basal NO.

Finding GF/SO/wife.