Cristina Malagelada's profile

I'm female

What I do

Neuronal cell death mechanisms in neurodegeneration in Parkinson’s disease and other neurodegenerative diseases

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Interests

I am interested in the molecular mechanisms that trigger neuronal death in neurodegeneration. In this context, I am focused on mTOR pathway and its regulators such as RTP801.

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Publications

  • Malagelada C, Ryu E, Biswas S, Jackson-Lewis V, Greene L. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. The Journal of neuroscience : the official journal of the Society for Neuroscience 26 (39) , 9996-10005 (2006) PubMed ID:(17005863)

  • Malagelada C, Xifró X, Miñano A, Sabriá J, Rodríguez-Alvarez J. Contribution of caspase-mediated apoptosis to the cell death caused by oxygen-glucose deprivation in cortical cell cultures. Neurobiology of disease 20 (1) , 27-37 (2005) PubMed ID:(16137564)

  • Malagelada C, Xifró X, Badiola N, Sabrià J, Rodríguez-Alvarez J. Histamine H2-receptor antagonist ranitidine protects against neural death induced by oxygen-glucose deprivation. Stroke; a journal of cerebral circulation 35 (10) , 2396-401 (2004) (Epub 19 Aug 2004) PubMed ID:(15322300)

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