Christine Keogh's profile
What I do
My research primarily focuses on the study of angiogenesis after neonatal stroke. Pathophysiological mechanisms of the disease are not yet clear and currently few treatments exist. Angiogenesis, or the growth of new blood vessels from an existing vasculature, occurs in the brain after stroke. My project aims to establishing an angiogenic time course and profile the expression of various angiogenic growth factors after stroke. We are also using a phenomenon known as hypoxic preconditioning to try and increase the amount of angiogenesis after stroke. Finally, we are administering a treatment of recombinant human erythropoietin after stroke in order to enhance both the angiogenic response as well as the neurogenic response. Our ultimate goal is to increase the reparative ability of the brain in order to achieve successful neurovascular remodeling that will improve functional recovery.
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Publications
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Angiogenesis and stem cell transplantation as potential treatments of cerebral ischemic stroke. Pathophysiology : the official journal of the International Society for Pathophysiology / ISP. (1) , 47-62 PubMed ID:(15927824)
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The Effect of Recombinant Human EPO on Neurovasculature Repair after Focal Ischemic Stroke in Neonatal Rats. (Epub 09 May 2007) PubMed ID:(17494864)
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Gonzalez-Nicolini M, Berglind W, Cole K, Keogh C, McGinty J. Local mu and delta opioid receptors regulate amphetamine-induced behavior and neuropeptide mRNA in the striatum. Neuroscience (2) , 387-98 PubMed ID:(14521997)
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Li Y, Lu Z, Keogh C, Yu S, Wei L. Erythropoietin-induced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (5) , 1043-54 (Epub 01 Nov 2006) PubMed ID:(17077815)
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Wei L, Han B, Li Y, Keogh C, Holtzman D, Yu S. Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats. The Journal of pharmacology and experimental therapeutics (1) , 109-16 (Epub 15 Dec 2005) PubMed ID:(16357210)
Contact
- email:
- keogh [ at ] musc.edu
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