• Eduardo Candelario-Jalil's profile

    I'm 33

    • What I do

      Research involves studies on the role of matrix metalloproteinases in neuroinflammation and ischemic brain injury.

    • Affiliations

      Current

    • Interests

      RESEARCH INTERESTS:

      - Cerebral ischemic brain injury (global and focal cerebral ischemia).

      - Neuropathological mechanisms of stroke.

      - Neurodegeneration and neuroprotection

      - Neuroregeneration and neurorestorative strategies for stroke

      - Cyclooxygenases, prostaglandins, prostanoid receptors, neuroinflammation

      - Matrix metalloproteinases in neuroinflammation and cerebral ischemia

      - Excitotoxicity, neuronal damage induced by oxidative stress, neuronal apoptosis

      - Signal transduction pathways regulating the production of pro-inflammatory mediators (e.g., prostaglandin E2, IL-1b, TNF-a) after ischemic brain injury

      - Natural antioxidant compounds and vitamins, free radical biology, antioxidant enzymes

    • Projects

      Research involves studies on the role of matrix metalloproteinases and cyclooxygenases in neuroinflammation and ischemic brain injury.

    • Publications

      • Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. Journal of neuroinflammation [electronic resource]. 2 (1) , 3 (Epub 18 Jan 2005) PubMed ID:(15656909)

      • Akundi R, Candelario-Jalil E, Hess S, Hüll M, Lieb K, Gebicke-Haerter P, Fiebich B. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia 51 (3) , 199-208 PubMed ID:(15800925)

      • Candelario-Jalil E, Ajamieh H, Sam S, Martínez G, León Fernández O. Nimesulide limits kainate-induced oxidative damage in the rat hippocampus. European journal of pharmacology 390 (3) , 295-8 PubMed ID:(10708736)

      • Candelario-Jalil E, Akundi R, Bhatia H, Lieb K, Appel K, Muñoz E, Hüll M, Fiebich B. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. Journal of neuroimmunology 174 (1-2) , 39-51 (Epub 10 Mar 2006) PubMed ID:(16529823)

      • Candelario-Jalil E, Al-Dalain S, Castillo R, Martínez G, Fernández O. Selective vulnerability to kainate-induced oxidative damage in different rat brain regions. Journal of applied toxicology : JAT 21 (5) , 403-7 PubMed ID:(11746182)

      view all

    • Contact

      email:
Sign in

New to Nature Network?
Sign up today!

Search people
Send an invite

Advertisement