Bryan Downie's profile

I'm 35

What I do

Eag1 is a voltage-dependent potassium ion channel, normally only expressing the CNS, that has been implicated in tumor formation. Our research suggests that Eag1 contributes to oncogenesis by interfering with the normal cellular oxygen homeostasis pathway that regulates angiogenesis and metabolism.

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Publications

  • Weber C, Mello de Queiroz F, Downie B, Suckow A, Stühmer W, Pardo L. Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference. The Journal of biological chemistry 281 (19) , 13030-7 (2006) (Epub 14 Mar 2006) PubMed ID:(16537547)

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