Michael Roberts' profile
What I do
Solving protein structures by X-ray crystallography. Improvement of structure determination methods in protein crystallography. Supervision of students on protein crystallography projects. Biomedical research using a combination of biochemical and biophysical methods. Documentation of results and publication.
Teaching in higher education.
Affiliations
Current affiliations
-
- Position
- X-ray Crystallographer/Research Scientist
- Company
- Global Phasing Limited
- Further information
Location
- City:
- None chosen
- Hub:
- London
Interests
Protein crystallography, virology, chemistry, natural products, molecular structure, science teaching.
Projects
Current work is focussed on viral RNA polymerases and a revised definition of solvent structure as an improvement to protein structure determination.
Previous projects:
The anti-viral action of arbidol.
Structure determination of Mycobacterium tuberculosis chaperonin 10.
Structure and function of proteins of tuberculosis and the human immunodeficiency virus.
The action of retroviral protease in the early stage of infection.
Study of the ultrastructure of retroviral capsids using electron microscopy.
Structure determination of the adenovirus coat protein by X-ray crystallography.
Publications
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al-Ghusein H, Ball H, Igloi G, Gbewonyo A, Coates A, Mascagni P, Roberts M. Chemically synthesised human immunodeficiency virus P7 nucleocapsid protein can self-assemble into particles and binds to a specific site on the tRNA(Lys,3) primer. Biochemical and biophysical research communications (1) , 191-8 PubMed ID:(8694811)
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Boriskin Y, Booth J, Roberts M, Carrington D, Coates A. HIV primers can amplify sequences of human satellite DNA. AIDS (London, England) (5) , 709-11 PubMed ID:(8060556)
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Copeland T, Wondrak E, Tozser J, Roberts M, Oroszlan S. Substitution of proline with pipecolic acid at the scissile bond converts a peptide substrate of HIV proteinase into a selective inhibitor. Biochemical and biophysical research communications (1) , 310-4 PubMed ID:(2190554)
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Fossati G, Cremonesi P, Izzo G, Rizzi E, Sandrone G, Harding S, Errington N, Walters C, Henderson B, Roberts M, Coates A, Mascagni P. The Mycobacterium tuberculosis chaperonin 10 monomer exhibits structural plasticity. Biopolymers (2) , 148-62 PubMed ID:(15356869)
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Fossati G, Izzo G, Rizzi E, Gancia E, Modena D, Moras M, Niccolai N, Giannozzi E, Spiga O, Bono L, Marone P, Leone E, Mangili F, Harding S, Errington N, Walters C, Henderson B, Roberts M, Coates A, Casetta B, Mascagni P. Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane? Journal of bacteriology (14) , 4256-67 PubMed ID:(12837802)
Contact
- email:
- mroberts [ at ] globalphasing.com
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