Muthuswamy Balasubramanyam's profile
What I do
Dr.M.Balasubramanyam is Assistant Director & Senior Scientist, Cell and Molecular Biology at the MDRF. He is a member of the Asia-Pacific International Molecular Biology Network (A-IMBN) and had an extensive post-doctoral training (1991-95) at the Hypertension Research Centre, New Jersey Medical School, USA, in the areas of signal transduction in health and metabolic diseases with special reference to molecular pathogenesis of Type 2 diabetes and vascular biology. Having worked as a faculty at the Center for Biotechnology, Anna University, Chennai for 3 years (1996-99) he has joined MDRF in 1999. He is instrumental in setting up the basic infrastructural facilities at MDRF and coordinates various research programmes and educational activities from time-to-time.
Mission & Vision: Dr.Balu’s laboratory is involved in studying cell and molecular signatures with special reference to insulin secretion, insulin action and vascular function. Our research integrates physiological and pharmacological approaches with biochemical, molecular biological and proteomics techniques to study mechanisms underlying development and progression of diabetes, its complications and cardiovascular diseases.
Affiliations
Current affiliations
-
- Position
- Assistant Director & Senior Scientist
- Company
- Madras Diabetes Research Foundation
- Further information
Location
- City:
- None chosen
- Hub:
- None chosen
Interests
Insights into biochemistry and molecular biology of diabetes and its vascular complications by studying nutrient-sensing pathways, redox signaling, advanced glycation end products, calcium signaling and epigenetic mechanisms.
Investigating the role of organellar dysfunction (Endoplasmic reticulum (ER) stress and mitochondrial mess) in insulin resistance and Type 2 diabetes utilizing the target tissue specific (skeletal muscle, adipose, β-cell) microarray, proteomics, siRNA and epigenetics studies.
Bio-prospecting biomarker(s) potential in body fluids and tissue biopsies (human skeletal muscle and adipocytes) adapting to proteomic tools and identification of prediabetes/diabetes/diabetic complications-specific molecular fingerprints and protein post-translational modifications.Studying telomere biology and test whether shortening of telomeres are related to inter-individual differences in biological ageing that predisposes one to ‘lifestyle diseases’ and serve as a long-term biomarker.
Demonstration of oxidative stress as a therapeutic target, testing natural products (herbals, marine resources) from the Indian biodiversity for their molecular actions beyond antioxidant property and validation of their utility as novel insulin secretatgogues/insulin sensitizers/vascular protectants.
Projects
Diabetes and its Vascular complications
Hyperglycemic memory
Proteomics and epigenetics of diabetes
miRNA profiling and RNA silencing
Oxidative stress
Bioprospecting of herbal drugs
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