• Afshin Raouf's profile

    • What I do

      I am a stem cell biologist interested in identifying signaling molecules involved in the regular differentiation of stem and progenitor cells since these pathways are deregulated in these cells to give rise to cancer initiating cells.

    • Affiliations

      Current

    • Interests

      I am interested in the application of the cancer stem cell concept to devising new therapies to target these rare cells specifically.

    • Projects

      1).Isolation and characterization of human mammary epithelial progenitors
      2). Identification of unique NOTCH target genes involved in the differentiation of bipotential mammary progenitors to the lineage-restricted progenitors.
      3). Isolation and characterization of cancer stem cells from solid tumours

    • Publications

      • Leong K, Niessen K, Kulic I, Raouf A, Eaves C, Pollet I, Karsan A. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. The Journal of experimental medicine 204 (12) , 2935-48 (2007) (Epub 05 Nov 2007) PubMed ID:(17984306)

      • Zhao Y, Raouf A, Kent D, Khattra J, Delaney A, Schnerch A, Asano J, McDonald H, Chan C, Jones S, Marra M, Eaves C. A modified polymerase chain reaction-long serial analysis of gene expression protocol identifies novel transcripts in human CD34+ bone marrow cells. Stem cells (Dayton, Ohio) 25 (7) , 1681-9 (2007) (Epub 05 Apr 2007) PubMed ID:(17412892)

      • Raouf A, Brown L, Vrcelj N, To K, Kwok W, Huntsman D, Eaves C. Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY. Journal of the National Cancer Institute 97 (17) , 1302-6 (2005) PubMed ID:(16145051)

      • Stingl J, Raouf A, Emerman J, Eaves C. Epithelial progenitors in the normal human mammary gland. Journal of mammary gland biology and neoplasia 10 (1) , 49-59 (2005) PubMed ID:(15886886)

      • Kitching R, Qi S, Li V, Raouf A, Vary C, Seth A. Coordinate gene expression patterns during osteoblast maturation and retinoic acid treatment of MC3T3-E1 cells. Journal of bone and mineral metabolism 20 (5) , 269-80 (2002) PubMed ID:(12203032 )

      view all
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