Nick Henriquez's profile
What I do
Currently I am engineering human breast cancer cells for in vivo syngeneic transgene studies by adding a luciferase gene and a recombinase insertion site (“flip-in”).
Affiliations
Current affiliations
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- Position
- Research Fellow
- Company
- Leiden University Medical Centre
- Further information
Location
- City:
- None chosen
- Hub:
- None chosen
Interests
In short, I want to kill off abnormal growths which cause pain and/or death and improve patients lives. Research alone is not (anymore) enough to satisfy me, it has to be applied.
I am interested in developmental pathology, e.g. rheumatoid arthritis, lupus erythematosus and cancer. I was trained as an immunologist in Utrecht, worked on EBV-induced transformation of B-cells in Birmingham UK, then on apoptotic abnormalities in RA and SLE (also in Birmingham) and after a short period in a small company I now investigate the interaction of bone-morphogenic protein/TGF-beta interactions in bone metastasis in human/mouse xenografts.
Projects
Receptor Cross-talk in human B-cell signalling
EBV-LMP1 mediated effects in human B-cells
RGD-peptide mediated apoptosis in lymphocytes
Apoptin-mediated cell-death in rheumatoid-arthritis synovial fibroblasts
TGF-beta/BMP mediated effects on bone-metastatic disease
Novel imaging modalities for in vivo imaging of (bone) metastatic disease
Publications
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Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using (99m)Tc-sestamibi. (Epub 01 Jun 2007) PubMed ID:(17541583 )
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Buckley C, Pilling D, Henriquez N, Parsonage G, Threlfall K, Scheel-Toellner D, Simmons D, Akbar A, Lord J, Salmon M. RGD peptides induce apoptosis by direct caspase-3 activation. Nature (6719) , 534-9 PubMed ID:(10028971 )
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Groot P, Mager W, Henriquez N, Pronk J, Arwert F, Planta R, Eriksson A, Frants R. Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers. Genomics (1) , 97-105 PubMed ID:(2081604 )
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Henriquez N, Floettmann E, Salmon M, Rowe M, Rickinson A. Differential responses to CD40 ligation among Burkitt lymphoma lines that are uniformly responsive to Epstein-Barr virus latent membrane protein 1. Journal of immunology (Baltimore, Md. : 1950) (6) , 3298-307 PubMed ID:(10092782 )
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Henriquez N, Rijkers G, Zegers B. Antigen receptor-mediated transmembrane signaling in Wiskott-Aldrich syndrome. Journal of immunology (Baltimore, Md. : 1950) (1) , 395-9 PubMed ID:(7515927 )
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