Iain Kerr's profile
What I do
My current research is broadly concerned with the mechanism of action, and inhibition, of cysteine-proteases; specifically those implicated during the progression of infectious disease.
Broad-spectrum resistance continues to limit the effectiveness of current antimicrobials and drives research focused on novel classes of drugs.
Proteases are, generally, well-validated, druggable targets with the HIV-1 protease being a classic example.
Structure-based drug design is an excellent tool to allow us to develop rational structure-activity relationships (SAR) that will lead inhibitor design and optimization.
Affiliations
Current affiliations
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- Position
- Senior Scientist (specialist II)
- Company
- University of California San Francisco
- Duration
- 2007 - Present
Location
- City:
- None chosen
- Hub:
- None chosen
Interests
X-ray Crystallography
Protein structure
Enzyme mechanism
Proteases
Linux development
Projects
Iain Kerr has not yet listed any projects.
Publications
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Kerr I, Sivakolundu S, Li Z, Buchsbaum J, Knox L, Kriwacki R, White S. Crystallographic and NMR analyses of UvsW and UvsW.1 from bacteriophage T4. The Journal of biological chemistry (47) , 34392-400 (2007) (Epub 17 Sep 2007) PubMed ID:(17878153)
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A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose. Biochem Soc Trans , 532-536 (2003) PubMed ID:(12773151)
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Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein. EMBO journal , 2561-2570 (2003) PubMed ID:(12773373)
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Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode. Structure , 773-786 (2002) PubMed ID:(12057193)
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Overexpression, purification, crystallization and data collection of a single-stranded DNA-binding protein from Sulfolobus solfataricus Acta Crystallographica D , 1290-1292 (2001) (Epub 23 Aug 2001) PubMed ID:(11526322)
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