Dustin Armstrong's profile

What I do

I am a Postdoctoral fellow in the Epigenetics Department at Novartis. My research projects focus on identifying compounds to activate adult stem cells.

Affiliations

Current

Location

City:
None chosen
Hub:
Boston

Interests

Besides my research at Novartis, I am very interested in biotech start-ups and would like to develop my own business focused on targeted drug delivery, 4s3 Bioscience, Inc.

Projects

4s3 Bioscience, Inc. is committed to developing novel technologies for Smarter, Stronger, and Safer treatment of human disease. We are currently pursuing IP protection for two innovative methodologies for targeted drug-delivery. The first, originating from our combined expertise in muscle biology and prodrug chemistry, utilizes the unique microenvironment of muscle cells, including enzyme expression and pH state, to specifically target small-molecules to skeletal and/or cardiac muscle tissue. The second, involves a transcendent modification to basic electrophoresis which could revolutionize intradermal drug-delivery. For both applications, through partnership or in-licensing, we
will obtain small-molecules with proven efficacy but which are not being pursued due to safety concerns. Using our targeted drug-delivery technologies, we will unmask the true therapeutic potential of these compounds, increasing their potency and reducing potential side-effects.

Publications

  • Expression of beta-catenin is necessary for physiological growth of adult skeletal muscle Am J Physiol Cell Physiol 291(1) , 185-188 (2006) (Epub 25 Jan 2006) PubMed ID:(16436469)

  • Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction. Am J Physiol Cell Physiol 288(1) , 185-194 (2005) (Epub 15 Sep 2004) PubMed ID:(15371259)

  • Wnt/beta-catenin signaling activates growth-control genes during overload-induced skeletal muscle hypertrophy. Am J Physiol Cell Physiol 289(4) , 853-859 (2005) (Epub 11 May 2005) PubMed ID:(15888552)

  • Selenoprotein-deficient transgenic mice exhibit enhanced exercise-induced muscle growth. J Nutrition 133(10) , 3091-3097 (2003) PubMed ID:(14519790)

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