Emma Wise's profile

I'm female

What I do

I am currently involved in elucidating the molecular basis of the activation of the G protein coupled receptor, CCR3. A chemokine receptor expressed on Th2 cells, eosinophils, basophils and mast cells all key players in the allergic response.

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Hub:
London

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Publications

  • Wise EL, Pease JE.. Unravelling the mechanisms underpinning chemokine receptor activation and blockade by small molecules: a fine line between agonism and antagonism? Biochem. Soc. Trans. 35 , 755-759 (2007)

  • Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation. (Epub 16 Jul 2007) PubMed ID:(17635911 )

  • Pennington D, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise E, Tigelaar R, Owen M, Hayday A. The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nature immunology 4 (10) , 991-8 (Epub 21 Sep 2003) PubMed ID:(14502287 )

  • Pennington D, Vermijlen D, Wise E, Clarke S, Tigelaar R, Hayday A. The integration of conventional and unconventional T cells that characterizes cell-mediated responses. Advances in immunology 87 , 27-59 PubMed ID:(16102571)

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