• Joel Neilson's profile

    Boston

    • What I do

      Use of the mammalian immune system, particularly T lymphocytes, to identify and characterize novel modes of gene regulation.

    • Affiliations

      Current

    • Interests

      The discovery of RNAi and microRNAs has underscored the importance of gene regulation at the RNA level. I am interested in all facets of this regulation, from alternative promoter usage to alternative splicing to translational control by nucleic acid and protein components. Using the mouse as a model, I intend to further develop our understanding of existing paradigms of gene regulation at the RNA level. This goal will be extended by initiating collaborative efforts with clinical researchers to understand the impact of these processes in cancer and other human diseases.

    • Projects

      Established and implemented a novel method for unbiased profiling of known and novel short RNA species from limiting amounts of primary biological material. Developed a gene therapy approach for microRNA loss-of-function analysis in vitro and in vivo. Expanding these findings by studying microRNA expression dynamics and post-transcriptional regulation of microRNA function. Using Affymetrix exon arrays to identify novel RNA-level gene regulation events following activation of T lymphocytes.

    • Publications

      • Arron J, Winslow M, Polleri A, Chang C, Wu H, Gao X, Neilson J, Chen L, Heit J, Kim S, Yamasaki N, Miyakawa T, Francke U, Graef I, Crabtree G. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441 (7093) , 595-600 (Epub 22 Mar 2006) PubMed ID:(16554754)

      • Chang C, McDill B, Neilson J, Joist H, Epstein J, Crabtree G, Chen F. Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. The Journal of clinical investigation 113 (7) , 1051-8 PubMed ID:(15057312)

      • Chang C, Neilson J, Bayle J, Gestwicki J, Kuo A, Stankunas K, Graef I, Crabtree G. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell 118 (5) , 649-63 PubMed ID:(15339668)

      • DavĂ© V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, Wert S, Neilson J, Crabtree G, Whitsett J. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. The Journal of clinical investigation 116 (10) , 2597-609 (Epub 21 Sep 2006) PubMed ID:(16998587)

      • Ebert M, Neilson J, Sharp P. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nature methods 4 (9) , 721-6 (Epub 12 Aug 2007) PubMed ID:(17694064)

      view all
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