Sarah Hoey's profile
What I do
PhD – Regulation of APP by Glutamatergic and Neurotrophin signalling: My research follows the logic that we can not understand what happens during disease until we can understand what is normal. As such we are investigating normal, physiological regulation of APP processing in primary cortical neurones by glutamatergic and neurotrophin singalling mechanisms. This involves various molecular and cellular biochemical techniques to investigate changes in APP processing.
Affiliations
Current affiliations
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- Position
- PhD student
- Company
- Wolfson Centre for Age-Related Diseases, King's College London
- Further information
Location
- City:
- None chosen
- Hub:
- London
Interests
My general interest is in Neuroscience, spefically in neurodegenerative disorders. My current interest is in Alzheimer’s disease and the mis-processing of Amyloid Precursor Protein (APP) in cortical neurones. My MSc lab project (with Dr. Micheal Perkinton at Kings College, London) investigated the application of a fluoroscent assay to monitor APP beta-secreatse activity, while my BSc lab project (with Dr. Julian Thorpe at the University of Sussex) focused on the Tauopathies and tau hyperphosphorylation is post mortem tissue from FTD-17 and CBD patients.
Projects
Regulation of APP by Glutamatergic and Neurotrophin signalling.
Publications
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Thorpe J, Mosaheb S, Hashemzadeh-Bonehi L, Cairns N, Kay J, Morley S, Rulten S. Shortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias. Neurobiology of disease (2) , 237-49 (2004) PubMed ID:(15474361)
Sarah Hoey's activity on Nature Network
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