Kuo-Chen Chou's profile
What I do
Author of over 320 scientific papers.
• Associate Editor of Medicinal Chemistry (2004 – present).
• Bioinformatics Section Editor of Amino Acids (2004 – present)
• Editor of Protein & Peptide Letters for Western USA region (2006 – present)
• Member of the Editorial Board of Journal of Theoretical Biology (2005 – present).
• Member of the Editorial Advisory Board of Current Protein and Peptide Science – The international journal for timely in-depth reviews in protein and peptide science (June 2000 – present).
• Member of the Editorial Board of the Open Biochemistry Journal (2007 – present)
• Member of the Editorial Board of the Current Proteomics (2007 – present)
• Member of the Editorial Board of Cancer Therapy – The international journal for rapidly publishing original and in-depth review articles on cancer embracing all fields from molecular mechanisms to results on clinical trials (2003 – 2005).
• Guest Editor for Current Medicinal Chemistry (2004, Vol.16, Number 11), the leading review journal in the area of medicinal chemistry.
• Guest Editor for Current Protein & Peptide Science (2005, Vol.6, No.5), the international journal for timely in-depth reviews in Protein & Peptide Science.
Affiliations
Current affiliations
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- Position
- Chief Scientist
- Company
- Gordon Life Science Institute
- Further information
Location
- City:
- None chosen
- Hub:
- None chosen
Interests
(1) Prediction and modeling of drug-discovery-related proteins, such as GABA receptors, SARS coronavirus proteinase, apoptosis proteins, membrane ion-channels, G-protein-coupled receptors, adhesion proteins, growth hormones, tau protein kinases, GFAT (for diabetes), b-secretases (for Alzheimer disease), antifreeze proteins, dopmin receptors, as well as those targeted for finding drugs against various infectious diseases and CNS diseases. (2) Development of various novel methods in bioinformatics and proteomics, such as predicting HIV protease cleavage sites, protein subcellular location, membrane protein type, signal peptide, protein quaternary attribute, enzyme family classes and sub-classes, enzyme active sites, protein tight turns, and protein structural classes. (3) Introduction of physical conceptions to elucidate various marvelous dynamic mechanisms in biomacromolecules, such as allosteric transition, cooperativity effects, and intercalation between DNA and drugs. (4) Development of graphical rules for studying enzyme kinetics and protein folding dynamics. (5) Investigation of protein structural characters and revelation of their origin. (6) Introduction of diagrammatic approach for codon usage analysis. (7) Investigation of internal collective motion of biomacromolecules and its biological functions.
Projects
Kuo-Chen Chou has not yet listed any projects.
Publications
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Du, Q. S., Huang, R. B., Wei, Y. T., Du, L. Q. & Kuo-Chen Chou. Multiple Field Three Dimensional Quantitative Structure-Activity Relationship (MF-3D-QSAR) Journal of Computational Chemistry , 211-219 (2008)
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Hong-Bin Shen and Kuo-Chen Chou. PseAAC: a flexible web-server for generating various kinds of protein pseudo amino acid composition Analytical Biochemistry , 386-388 (2008)
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Kuo-Chen Chou and Hong-Bin Shen. Cell-PLoc: A package of web-servers for predicting subcellular localization of proteins in various organisms Nature Protocols , 153-162 (2008)
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Wang, J. F., Wei, D. Q., Chen, C., Li, Y. & Kuo-Chen Chou. Molecular modeling of two CYP2C19 SNPs and its implications for personalized drug design Protein & Peptide Letters , 27-32 (2008)
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Zhang, T. L., Ding, Y. S. & Kuo-Chen Chou. Prediction protein structural classes with pseudo amino acid composition: approximate entropy and hydrophobicity pattern Journal of Theoretical Biology , 186–193 (2008)
Contact
- email:
- kcchou [ at ] gordonlifescience.org
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