I am a PhD student working experimental leishmaniasis and innate immunity. Trying to figure out what the principal difference between healing and nonhealing mice was, I came across the role of S-adenosyl methionine in the regulation of SOCS expression via DNA methylation and its involvement in polyamine synthesis. Realising that DNA methylation might be a fundamental part of the cellular time-keeping mechanism, I asked myself whether methionine’s role as universal start amino acid in protein synthesis might be linked to this rather than being merely a “frozen accident”. I tried to see if the genetic code could be rearranged in an effort to simplify the way it was presented. Placing the second base at the centre of the codon sun and “playing sudoku” with the genetic code made it possible to unite the codons for individual amino acids. The clustering of codons for amino acids with similar chemical properties perplexed me and I started to wonder whether information contained in the genetic code might be a reflection of the way in which translation occurred on a codon level. Perhaps codon bases were read in the order of 2-1-2-3 rather than 1-2-3 or simultaneously [123]...