• Biplab Bose's profile

    • What I do

      I am a faculty in the Department of Biotechnology, Indian Institute of Technology Guwahati, India.

    • Affiliations

      Current

      Past

    • Interests

      1)Therapeutic recombinant antibodies:

      I am interested in developing recombinant antibodies (and antibody fragments) for
      therapeutic uses against infectious diseases and in cancer immunotherapy. We use phage
      display technology for in vitro affinity maturation of antibodies and express them using
      bacterial and mammalian protein expression systems. Our work also involves, use of
      molecular modeling of antibodies to aid in in vitro mutagenesis and humanization.

      2) Theoretical Biology:

      I have general interest in different theoretical aspects of biological systems, particularly on Immune System, Signal Transduction, evolution and complex systems. I have earlier worked on the so called signature of affinity maturation in antibody sequences. We have shown that the conventional method of identification of such a signature is wrong, both philosophically and mathematically. We are currently working on the kinetics of B cell receptors and cellular heterogeneity.

    • Projects

      Biplab Bose has not yet listed any projects.

    • Publications

      • Bose B, Khanna N, Acharya S, Sinha S. Generation and characterization of a high-affinity chimaeric antibody against hepatitis B surface antigen. Biotechnology and applied biochemistry 43 (Pt 2) , 93-101 (2006) PubMed ID:(16253117 )

      • Bose B, Khanna N, Acharya S, Sinha S. Generation and characterization of a single-gene mouse-human chimeric antibody against hepatitis B surface antigen. Journal of gastroenterology and hepatology 21 (9) , 1439-47 (2006) PubMed ID:(16911690 )

      • Bose B, Khanna N, Acharya S, Sinha S. High affinity mouse-human chimeric Fab against hepatitis B surface antigen. World journal of gastroenterology : WJG 11 (48) , 7569-78 (2005) PubMed ID:(16437680 )

      • Bose B, Sinha S. Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection. Immunology 116 (2) , 172-83 (2005) PubMed ID:(16162266 )

      • Bose B, Chugh D, Kala M, Acharya S, Khanna N, Sinha S. Characterization and molecular modeling of a highly stable anti-Hepatitis B surface antigen scFv. Molecular immunology 40 (9) , 617-31 (2003) PubMed ID:(14597165 )

      view all
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