What I do
I have recently accomplished my PhD thesis. The work originated thanks to an initiative of the National Research Programm 50 on endocrine disruptors for which Dr. Serge Nef, my supervisor, received a grant. I started my PhD in Medical Biology in October 2004 in the laboratory of sexual development in Geneva, Switzerland.
Affiliations
Current affiliations
-
- Position
- Post Doc
- Company
- University of Geneva, Faculty of Medicine, Department of Genetic Medicine and Development
- Duration
- 2009 - Present
Past affiliations
-
- Position
- PhD student
- Company
- University of Geneva, Faculty of Medicine, Department of Medical Genetics and Development
- Duration
- 2004 - 2009
- Further information
Location
- City:
- Genève, Canton de Geneve, Switzerland
- Hub:
- Geneva
Interests
endocrine disruptors, metabolism, reproduction, soy, phytoestrogens, diethylstilbestrol … the more I learn, the more enthousiasm and endeavour I will have in my work.
Projects
The main interest of the laboratory remains male sexual development and therefore one of my projects aims at indentifying the molecular mechanisms by which exposure in utero to xeno-estrogens such as diethylstilbestrol act on the developing male sexual organ to inhibit testicular descent (cryptorchidism) and induce testis dysgenesis.
The second topic concerns a weaker endocrine disruptor : phytoestrogens. While assessing the effects of exposure to dietary soy on fertility, we observed than male mice exposed to doses at levels found in humans are leaner and have improved glucose tolerance. Now I have to unravel what are the molecular mechanisms that lead to such phenotype …
Publications
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Cederroth C, Nef S. Soy, phytoestrogens and metabolism: A review. Molecular and cellular endocrinology (1-2) , 30-42 (2009) (Epub 09 Mar 2009) PubMed ID:(19433245 )
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Alonso-Magdalena P, Ropero A, Carrera M, Cederroth C, Baquié M, Gauthier B, Nef S, Stefani E, Nadal A. Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS ONE (4) , e2069 (2008) (Epub 30 Apr 2008) PubMed ID:(18446233 )
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Cederroth C, Vinciguerra M, Gjinovci A, Kühne F, Klein M, Cederroth M, Caille D, Suter M, Neumann D, James R, Doerge D, Wallimann T, Meda P, Foti M, Rohner-Jeanrenaud F, Vassalli J, Nef S. Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Diabetes (5) , 1176-85 (2008) (Epub 16 Apr 2008) PubMed ID:(18420492 )
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Cederroth CR, Nef S. Diethylstilbestrol action on Leydig cell function and testicular descent Chimia , 401-405 (2008)
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Cederroth C, Schaad O, Descombes P, Chambon P, Vassalli J, Nef S. Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism. Endocrinology (11) , 5507-19 (2007) (Epub 02 Aug 2007) PubMed ID:(17673513)
Contact
- email:
- christopher.cederroth [ at ] medecine.unige.ch
