What I do
I split my time between doing NIH- and Industry-sponsored research, seeing patients with allergic diseases (as well as those with mast cell and eosinophilic disorders), teaching medical students, residents and postdoctoral fellows, and adminstration.
Affiliations
Current affiliations
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- Position
- Professor of Medicine and Director
- Company
- Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine
- Duration
- 2003 - Present
- Further information
Location
- City:
- Baltimore, Maryland, United States
- Hub:
- Washington DC-Baltimore
Interests
Ongoing work focuses on IgE, eosinophil, basophil and mast cell biology, with an emphasis on Siglec-8 and Siglec-F.
Projects
“Targeting Siglec-8/Siglec-F to Reduce Allergic Responses in vitro and in vivo” Agency: National Institutes of Health
“Novel Genetic and Therapeutic Approaches Focusing on Siglec-8 for the Diagnosis and Treatment of Human Idiopathic Eosinophilic Disorders”
Agency: Dana Foundation
“Efficacy of IgE in Mediating Allergic Reactions in Vivo – Project 1 (Principal Investigator: Bruce S. Bochner) Agency: National Institutes of Health
Publications
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Nutku-Bilir E, Hudson S, Bochner B. Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways. American journal of respiratory cell and molecular biology (1) , 121-4 (2008) (Epub 09 Aug 2007) PubMed ID:(17690326)
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Yokoi H, Choi O, Hubbard W, Lee H, Canning B, Lee H, Ryu S, von Gunten S, Bickel C, Hudson S, Macglashan D, Bochner B. Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. The Journal of allergy and clinical immunology (2) , 499-505.e1 (2008) (Epub 26 Nov 2007) PubMed ID:(18036650)
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Zimmermann N, McBride M, Yamada Y, Hudson S, Jones C, Cromie K, Crocker P, Rothenberg M, Bochner B. Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils. Allergy (9) , 1156-63 (2008) PubMed ID:(18699932)
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Yokoi H, Myers A, Matsumoto K, Crocker P, Saito H, Bochner B. Alteration and acquisition of Siglecs during in vitro maturation of CD34+ progenitors into human mast cells. Allergy (6) , 769-76 (2006) PubMed ID:(16677248)
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Bochner B, Alvarez R, Mehta P, Bovin N, Blixt O, White J, Schnaar R. Glycan array screening reveals a candidate ligand for Siglec-8. The Journal of biological chemistry (6) , 4307-12 (2005) (Epub 24 Nov 2004) PubMed ID:(15563466)
Network
Bruce Bochner's network is currently empty.
