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VERSION:2.0
CALSCALE:GREGORIAN
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BEGIN:VEVENT
LAST-MODIFIED:20070321T162248
SEQUENCE:0
CONTACT:events@imperial.ac.uk
ORGANIZER:Imperial College London
DTEND:20070322T173000
UID:2008-09-06T22:15:39-0400_333771605@socialweb1
DESCRIPTION:DNA double-strand breaks (DSBs) are one of the most lethal form
 s of DNA damage. Incorrectly repaired\, or unrepaired breaks can lead to gr
 oss chromosomal rearrangements\, aneuploidy and ultimately\, carcinogenesis
  and cell-death.  Non homologous end-joining (NHEJ) is a major DNA DSB repa
 ir pathway in both prokaryotes and eukaryotes. The prokaryotic NHEJ complex
 \, comprising Ku and DNA ligase\, assembles at DSBs to mediate repair of br
 oken DNA ends. I will discuss how we have used a variety of cellular\, bioc
 hemical and structural techniques to elucidate the mechanism of action of t
 he prokaryotic NHEJ repair complex and how these studies contribute to our 
 understanding of the molecular mechanisms that coordinate DNA break repair.
  We recently discovered Ku proteins in the genomes of phage and a direct ro
 le for NHEJ in viral life-cycle will also be discussed. References: Pitcher
  et al. (2007) J. Mol. Biol. 66\, 391–\; Bowater & Doherty (2006) PLOS Ge
 netics 2\, e8\; Pitcher et al. (2006) Mol. Cell 23\, 743-\; Della et al. (2
 004) Science 306\, 683-\; Weller et al. (2002) Science 297\, 1686-
SUMMARY:Many Ways to Make Ends Meet: Mechanisms of DNA double-strand break 
 repair by NHEJ
DTSTART:20070322T163000
CREATED:20070321T162247
DTSTAMP:20080906T221539
LOCATION:Imperial College London Sir Alexander Fleming Building Room 122
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