Host: Matt Bence

We have studied the origins and evolution of synapses using comparative proteomics and genomics. Striking changes in signalling complexity were observed at the yeast:metazoan and invertebrate:vertebrate boundaries, with expansion of key synapse components. We find that vertebrate-specific components preferentially contributed to differences between brain regions in mammals. We propose that evolution of synapse complexity around a core proto-synapse has contributed to invertebrate–vertebrate differences and to brain specialisation. The organisation of the phosphoproteome and the complexity of switching and regulation will be presented.

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