Systems biology approaches to angiogenesis will be presented that include molecular-detailed computational models of hypoxia-inducible factor (HIF), vascular endothelial growth factors (VEGF), and matrix metalloproteinases (MMPs), as well as agent-based model of capillary sprouting and neovascular network formation. The model of VEGF is extended from molecular to whole body level and is applied to investigate therapeutic pro-angiogenic interventions in peripheral arterial disease and anti-angiogenic interventions in cancer. Bioinformatic approaches to angiogenesis will also be presented that include proteome-wide search for novel anti-angiogenic peptides; we screen and validate the candidates in vitro in endothelial cell proliferation and migration assays and then in vivo using mouse models of cancer and ocular diseases.