CELLULAR AND GENOMIC STABILITY MECHANISMS IN CANCER AND OTHER DISEASES

Friday, 24 October

1:00 PM Welcome & Introduction

1:10 PM Lawrence Loeb, U. of Washington, JBL Award Lecture

“Mutator Phenotype in Human Cancer: Origin and Consequences”

2:00 PM David E. Fisher, HMS

“UV, Skin Signaling and Cutaneous Cancer Risk”

2:45 PM Frank McKeon, HMS

TBA

3:30 PM Break

4:00 PM Tanya Paull, UT-Austin

“Mre 11/Rad50 complexes and DNA double-strand break repair”

4:45 PM Craig Peterson, UMass Med. School

“Chromatin remodeling and genomic integrity”

5:30 PM Reception

Saturday, 25 October

8:00 AM Breakfast

9:00 AM Introduction

9:05 AM Pamela Silver, HMS

“Designing Biological Systems”

9:50 AM Myron Goodman, USC

“Better Living Through Hyper-Mutation”

10:35 AM Break

10:55 AM Thomas Kunkel, NIEHS

“Division of Labor at Yeast DNA Replication Forks”

11:40 AM Graham Walker, MIT

“Dealing With DNA Problems: Template Lesions and Replication Blocks”

12:25 PM Lunch

1:40 PM Introduction

1:50 PM Raul Mostoslavsky, MGH

" The role of the chromatin factor SIRT6 in glucose homeostasis "

2:35 PM Brian Dynlacht, NYU

“Regulation of Centrosome Duplication and Genome Stability”

3:20 PM Johannes Walter, HMS

“Mechanism of DNA Interstrand Cross-Link Repair in S-Phase”

4:05 PM General discussion and closing remarks