Events: detail
Runx2 is a Hub for Transcriptional Control of Skeletal Development
- Speaker:
-
Jane B. Lian, University of Massachusetts Medical School
- Starts:
- October 02, 2008 at 12:00 pm
- Ends:
- October 02, 2008 at 01:00 pm
- Location:
- The Forsythe Institute, Schulze Conference Room #2, 140 The Fenway, Boston, MA. 02115
- Maps:
Description
Runx2 is a master gene regulator of osteoblast differentiation and essential for embryonic bone formation. Human mutations in Runx2 result in the Cleidocranial Dysplasia Disorders. The multiple functions of Runx2 will be discussed for an appreciation of the novel concepts that explain properties of how a master transcription factor controls a cell phenotype. For example, Runx2 has epigenetic functions in mesenchymal stems and regulates the progression of osteogenesis as a scaffolding protein interacting with mediators of pathways critical for skeletal development (TGFâ, BMP, Wnt, Homeobox).
- Registration required:
- No
- Free:
- Yes
For more information
- Contact person:
- Pam Quattrocchi
- Email:
- pquattrocchi [ at ] forsyth.org
- Website:
- Runx2 is a Hub for Transcriptional Control of Skeletal Development
