8:15 AM Welcome Mark L. Zeidel, Beth Israel Deaconess Medical Center 8:20 AM Opening Remarks Robert Schwartz, New England Journal of Medicine/ Chairs: Elisabeth W. Karlson, M.D., Elena Massarotti, M.D.; Arlene H. Sharpe, M.D., Ph.D., Vicki Rubin-Kelley, Ph.D./ Speakers: Antibodies and Brain Disease: A Convergence of Immunology and Physiology Betty Diamond,The Feinstein Institute for Medical Research/ Epstein-Barr virus infection induces lupus autoimmunity. Judith James, Oklahoma Medical Research Foundation/ Human neutrophil activation by SLE nucleic acid-containing immune complexes Terry K. Means, Massachusetts General Hospital/ Perinatal Characteristics and Adult-Onset SLE in Women Julia Simard-Fridmam, Harvard School of Public Health/ A common complement receptor 2 haplotype confers increased risk of SLE Betty P. Tsao, UCLA School of Medicine/ Pathogenesis of congenital heart block Jill P. Buyon, NYU Medical Center/ CaMKIV-CREM Activation in SLE T cells Yuang-Taung Juang, Beth Israel Deaconess Medical Center/ TCR zeta mRNA Stability Vaishali Moulton, Beth Israel Deaconess Medical Center/ Interferon Pathways in Lupus Peggy Crow, Weill Medical College of Cornell University/ Tolerogenic treatment of lupus mice Bevra H. Hahn, UCLA School of Medicine/ Autoreactive B cell activation by chromatin IC is dependent on HMGB1-surface RAGE interaction Ana Avalos, Boston University/ Dissecting Osteoclast Development with RNAi Antonios Aliprantis, Brigham and Women’s Hospital/ The Sle1c Murine Lupus Susceptibility Interval Laurence Morel, University of Florida/ TLR7-dependent loss of B cell tolerance in pathogenic autoantibody knock-in mice Thereza Imanishi-Kari, Tufts University School of Medicine/ Ly108 isoforms in T and B cell function Svend Rietdijk,Beth Israel Deaconess Medical Center/ Nasal anti-CD3 monoclonal antibody suppresses murine lupus by inducing IL-10 producing Foxp3+CD4+CD25-LAP+ regulatory T cells Henry Yim Wu, Brigham and Women’s Hospital/ Closing Remarks George Tsokos, Beth Israel Deaconess Medical Center