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LOCATION:Massachusetts General Hospital Thier 1 
SEQUENCE:0
CONTACT:ndevoe@partners.org
ORGANIZER:Wellman Center for Photomedicine
DTEND:20060613T151500
DTSTART:20060613T140000
UID:2009-11-29T10:36:12-05:00_112417811@socialweb1
DTSTAMP:20091129T103612
DESCRIPTION:We introduced an RNA binding site for the amino acid tryptophan
  into RNAs that bind to phospholipid bilayer membranes. The resulting hybri
 d RNA (9:10Trp) still binds tryptophan with specificity and is also still a
 ble to bind phosphatidylcholine membranes as detected by gel filtration and
  FRET measurements between the intercalated green dye\, YOYO-1 in RNA and T
 exas Red in membranes. RNA (9:10Trp) serves specifically to passively carry
  tryptophan across the membrane\, without significant increase in general p
 ermeability. We previously found that membrane RNAs prefer the edges of lip
 id bilayer patches and other sites where irregular lipid conformations occu
 r. This suggests that membrane RNAs should stabilize distorted lipid confor
 mations\, probably including those formed at transient transmembrane pores.
  These results show that a small-molecule-specific membrane carrier can be 
 built of RNA\, and suggest that other nanoconstructions in which RNA activi
 ties are brought to the membrane would be successful.
SUMMARY:RNA-Membrane Nanoconstructions and Their Potential Applications in 
 Photomedicine
LAST-MODIFIED:20060612T123250
CREATED:20060609T125452
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