How to succeed in science: a concise guide for young biomedical scientists by Jonathan Yewdell. Part II: making discoveries Nature Reviews Molecular Cell Biology 9, 491-494 (June 2008) | doi:10.1038/nrm2390
Making discoveries is the most important part of being a scientist, and also the most fun. Young scientists need to develop the experimental and mental skill sets that enable them to make discoveries, including how to recognize and exploit serendipity when it strikes. Here, I provide practical advice to young scientists on choosing a research topic, designing, performing and interpreting experiments and, last but not least, on maintaining your sanity in the process.

See also Part I: Taking the plunge.