Nice work characterizing the effect of miR-125b on p53.

Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, Lodish HF, Lim B. MicroRNA-125b is a novel negative regulator of p53. Genes Dev. 2009 Apr 1;23(7):862-76. Epub 2009 Mar 17.

http://www.ncbi.nlm.nih.gov/pubmed/19293287

Cell culture and zebrafish models. Reporter plasmids with miRNA response elements. dsRNA and antisense delivery to cultures. Morpholinos targeting guide and loop sequences in zebrafish. Morphant rescue with dsRNA. These folks traversed many techniques to put their story together.