Closer to a mechanism of miRNA translation repression
Jon Moulton
Tuesday, 07 August 2007 22:47 UTC
Wakiyama M, Takimoto K, Ohara O, Yokoyama S. Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev. 2007 Aug 1;21(15):1857-62.
http://www.genesdev.org/cgi/content/full/21/15/1857
The authors propose that when a miRNA brings Argonaute and GW182 to a target mRNA, the mRNA poly-A tail is removed, preventing the required interaction of poly-A binding protein and the initiation factor eIF4G and therefore inhibiting translation.
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