Synergism or Additivity.
D Baunbaek
Friday, 16 November 2007 11:51 UTC
How do you dinstinguish between synergism and additivity if you have dose curves of 1. drug and 2. drug together and separately? I have looked at the article “Chou T, Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies”. In this paper they give the formula, but I’m not sure I’m using it right. Any help?
Updated 16 November 2007 11:52 UTC
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Replies
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You can use the software called calcusyn, (http://www.biosoft.com/) there you can easily calculate the combinatorial index (CI) values which shows whether your drug combination is synergistic, additive or antagonistic etc..
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For clarification, what’s the specific formula that you are referring to? The article can be found here.
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have you looked at the hill slope of the dose response curves?
synergism will look like a multi slope fit and reduce the hill slope. strict additivity will just act like more of the same drug
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Thank you all very much for your help! Nice to have a network like this. :)
Actually I looked at that article and it seems like the programmes commercially available would be best but there’s none that’s for free unfortunately.
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