Calcium signalling Forum
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Calcium is the most ubiquitous ion and second messenger regulating a plethora of major cellular mechanisms from birth to death. Intracellular Ca2+ signals correspond to a cellular language; the parameters of which (amplitude, frequency, kinetic, spread) can be decoded and interpreted by specific proteins that consist of Ca2+ binding domains and lead to the modulation of kinase activities and to phosphorylation events.
A huge amount of work has been done in this field over the last 20 years, but:
i)What’s new now?
ii)What do we still need to investigate?
iii)What needs to be deciphered?
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