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The neuroscience of honesty/wisdom ?

Charlie Stromeyer

Tuesday, 28 Jul 2009 13:28 UTC

Hi,

Do you suppose that these two discoveries might be related somehow? However, they each involve the dlPFC and the ACC in different ways:

The neuroscience of wisdom:

http://www.scientificamerican.com/blog/60-second-science/post.cfm?id=is-wisdom-in-the-brain-2009-04-06

The neuroscience of honesty:

http://www.harvardscience.harvard.edu/culture-society/articles/neuroimaging-suggests-truthfulness-requires-no-act-will-honest-people

Also, it would seem that honesty is more innate than wisdom which is more acquired. Further, in schizophrenia, there are neurobiological deficits in both the dlPFC and in the ACC, and these two brain regions have somewhat different methods in controlling cognition:

Neuron. 2009 Feb 26;61(4):609-20.

Synapses with inhibitory neurons differentiate anterior cingulate from dorsolateral prefrontal pathways associated with cognitive control.

Medalla M, Barbas H.
Department of Health Sciences, Boston University and School of Medicine, Boston, MA 02215, USA.

The primate dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) focus attention on relevant signals and suppress noise in cognitive tasks. However, their synaptic interactions and unique roles in cognitive control are unknown. We report that two distinct pathways to DLPFC area 9, one from the neighboring area 46 and the other from the functionally distinct ACC, similarly innervate excitatory neurons associated with selecting relevant stimuli. However, ACC has more prevalent and larger synapses with inhibitory neurons and preferentially innervates calbindin inhibitory neurons, which reduce noise by inhibiting excitatory neurons. In contrast, area 46 mostly innervates calretinin inhibitory neurons, which disinhibit excitatory neurons. These synaptic specializations suggest that ACC has a greater impact in reducing noise in dorsolateral areas during challenging cognitive tasks involving conflict, error, or reversing decisions, mechanisms that are disrupted in schizophrenia. These observations highlight the unique roles of the DLPFC and ACC in cognitive control.



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