Recent replies to "JOURNAL CLUB: Curbing cocaine addiction using gene therapy" http://network.nature.com/forums/neuroscience/1479 en-us 40 <p>Hey Michael,</p> <p>Thank you for your question. The dopamine D2 receptor gene therapy reported on in the paper above may treat one aspect of drug addiction, but would probably not be as effective in humans. Dopamine D2 receptor dysfunction in the nucleus accumbens is just one characterisitc of drug addiction. Other areas of the brain in particular the prefrontal cortex and the cortico-striatal circuitry are thought to be central to drug addiction. <a href="http://www.nature.com/neuro/journal/v8/n11/full/nn1579.html">Here is a review</a> detailing the neural systems involved in addiction.</p> <p>Aine</p> Wed, 28 May 2008 14:11:20 -0000 http://network.nature.com/forums/neuroscience/1479?page=1#reply-4428 Aine Duffy http://network.nature.com/forums/neuroscience/1479?page=1#reply-4428 <p>nice article mate. but will the test on rats have the same effect on humans?</p> <p>micheal smith</p> <p>Addiction treatment and recovery resources for the addict and their families. http://www.addictiontreatment.net<br /><a href="http://www.addictiontreatment.net">text to link</a></p> Mon, 26 May 2008 13:14:45 -0000 http://network.nature.com/forums/neuroscience/1479?page=1#reply-4362 MICHEAL SMITH http://network.nature.com/forums/neuroscience/1479?page=1#reply-4362